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SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.2
USERS' SCORE
Good
Based on 8 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Vitamin B6 aids heart recovery
Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice.
Strong relevance to heart health
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
Read More
9
Pyridoxamine improves post-MI outcomes
Pyridoxamine improves survival and limits cardiac dysfunction after MI.
Directly addresses vitamin B6 effectiveness
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Read More
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Significant findings on heart health
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
Read More
Most Useful Reviews
9.5
Homocysteine reduction
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
Read More
9.5
Improves heart function
This effectively reduces homocysteine for heart disease risk. Take it with Jarrow TMG, and it may normalise within two months. Just avoid coffee or tea when taking it.
Read More
7.5
Calms arrhythmia
When I take it, my heart arrhythmia calms down, which is beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.2
9
Vitamin B6 aids heart recovery
Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice.
Strong relevance to heart health
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
Read More
9
Pyridoxamine improves post-MI outcomes
Pyridoxamine improves survival and limits cardiac dysfunction after MI.
Directly addresses vitamin B6 effectiveness
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Read More
9
Exosomes enhance heart recovery post-MI
Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction.
Composite treatment complicates isolated benefits
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Significant findings on heart health
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
Read More
7
Potential role of vitamin B6
Potential Anti-Inflammatory Treatment of Ischemic Heart Disease.
Study evaluates vitamin B6 impact
We conducted a study to find out how vitamin B6, particularly in combination with other treatments, affects heart attack outcomes. Our research involved 80 participants who were monitored for various health markers over a year. We had an experimental group that received standard ischemic heart disease (IHD) treatment along with ampicillin, vitamin B complex, including B6, and other vitamins.
What we found is quite interesting. The treatment group showed a moderate improvement in the systolic function of the heart compared to those who didn’t receive vitamin B6 and additional treatments. Importantly, there was a significant reduction in major adverse cardiac events (MACE) for this group, highlighting a potential anti-inflammatory effect from the treatment regimen.
However, while vitamin B6 was part of this treatment package, we noted that it was challenging to assess its isolated impact on heart attack outcomes. This means that while we saw promising results, we can't definitively say how much of the benefit was directly due to vitamin B6 alone.
What we found is quite interesting. The treatment group showed a moderate improvement in the systolic function of the heart compared to those who didn’t receive vitamin B6 and additional treatments. Importantly, there was a significant reduction in major adverse cardiac events (MACE) for this group, highlighting a potential anti-inflammatory effect from the treatment regimen.
However, while vitamin B6 was part of this treatment package, we noted that it was challenging to assess its isolated impact on heart attack outcomes. This means that while we saw promising results, we can't definitively say how much of the benefit was directly due to vitamin B6 alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.8
9.5
Homocysteine reduction
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
9.5
Reduces thrombosis risk
An excellent supplement that effectively lowers homocysteine levels. High homocysteine increases thrombosis and the risk of heart attack and other cardiovascular diseases.
9.5
Improves heart function
This effectively reduces homocysteine for heart disease risk. Take it with Jarrow TMG, and it may normalise within two months. Just avoid coffee or tea when taking it.
8.8
Supports blood circulation
My mum was prescribed vitamin B to normalise blood circulation. This complex has all the required B vitamins and methyl folate, making it easy to take. We highly recommend it!
8
Recommended by doctor
After being diagnosed with a heightened risk of heart attack, my doctor recommended this product. I’m still taking it, and it seems worthwhile.
